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Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Pipeline Review, H2 2017

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Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Pipeline Review, H2 2017


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Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Pipeline Review, H2 2017



Executive Summary

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Pipeline Review, H2 2017

Summary

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) pipeline Target constitutes close to 8 molecules. Out of which approximately 6 molecules are developed by companies and remaining by the universities/institutes. The latest report Glial Cell Line Derived Neurotrophic Factor-Pipeline Review, H2 2017, outlays comprehensive information on the Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Glial-derived neurotrophic factor is a member of the cysteine-knot superfamily of growth factors. It promotes the survival and differentiation of dopaminergic neurons and was able to prevent apoptosis of motor neurons. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. The molecules developed by companies in Phase II and Preclinical stages are 2 and 4 respectively. Similarly, the universities portfolio in Phase II and Discovery stages comprises 1 and 1 molecules, respectively. Report covers products from therapy areas Central Nervous System and Ophthalmology which include indications Amyotrophic Lateral Sclerosis, Parkinson's Disease, Brain Ischemia, Neurodegenerative Diseases and Retinal Degeneration.

Furthermore, this report also reviews key players involved in Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

The report provides a snapshot of the global therapeutic landscape for Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)

The report reviews Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources

The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages

The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) targeted therapeutics and enlists all their major and minor projects

The report assesses Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type

The report summarizes all the dormant and discontinued pipeline projects

The report reviews latest news and deals related to Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) targeted therapeutics

Reasons to buy

Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Identify and understand the targeted therapy areas and indications for Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)

Identify the use of drugs for target identification and drug repurposing

Identify potential new clients or partners in the target demographic

Develop strategic initiatives by understanding the focus areas of leading companies

Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics

Devise corrective measures for pipeline projects by understanding Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) development landscape

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 4

Introduction 5

Global Markets Direct Report Coverage 5

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Overview 6

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Therapeutics Development 7

Products under Development by Stage of Development 7

Products under Development by Therapy Area 8

Products under Development by Indication 9

Products under Development by Companies 10

Products under Development by Universities/Institutes 12

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Therapeutics Assessment 14

Assessment by Mechanism of Action 14

Assessment by Route of Administration 16

Assessment by Molecule Type 18

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Companies Involved in Therapeutics Development 20

GlaxoSmithKline Plc 20

Treeway BV 20

UniQure NV 20

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Drug Profiles 22

AMT-090-Drug Profile 22

Product Description 22

Mechanism Of Action 22

R&D Progress 22

Drugs for Neurodegenerative Diseases-Drug Profile 24

Product Description 24

Mechanism Of Action 24

R&D Progress 24

Fusion Protein to Activate GDNF for Brain Ischemia-Drug Profile 25

Product Description 25

Mechanism Of Action 25

R&D Progress 25

GSK-812-Drug Profile 26

Product Description 26

Mechanism Of Action 26

R&D Progress 26

LAUR-301-Drug Profile 27

Product Description 27

Mechanism Of Action 27

R&D Progress 27

smilagenin-Drug Profile 28

Product Description 28

Mechanism Of Action 28

R&D Progress 28

Stem Cell Therapy to Activate GDNF for Amyotrophic Lateral Sclerosis-Drug Profile 31

Product Description 31

Mechanism Of Action 31

R&D Progress 31

TW-002-Drug Profile 33

Product Description 33

Mechanism Of Action 33

R&D Progress 33

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Dormant Products 34

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF)-Product Development Milestones 35

Featured News & Press Releases 35

Oct 20, 2016: Cedars-Sinai Receives Approval to Test Novel Combined Stem Cell and Gene Therapy for ALS Patients 35

Apr 19, 2016: Lauren Sciences awarded second grant for LAUR-301 from The ALS Association 36

Nov 28, 2013: Clinical trial launched to treat Sanfilippo B syndrome using gene therapy 37

Mar 26, 2013: Phytopharm Provides Strategic Review Update On On-going Phase II Clinical Trial Of Cogane 37

Feb 18, 2013: Phytopharm Announces Results From Parkinson's Disease Clinical Trial Of Cogane 38

Dec 18, 2012: Phytopharm Provides Update On Clinical Development Of Cogane In Amyotrophic Lateral Sclerosis 39

Apr 18, 2012: Phytopharm Completes Patient Recruitment In CONFIDENT-PD Phase II Cogane Study To Treat Parkinson's Disease 40

Apr 18, 2012: Phytopharm's Confirmatory Data Supports Effectiveness Of Phytopharm's Cogane In Amyotrophic Lateral Sclerosis 40

Jan 16, 2012: Phytopharm's Cogane Demonstrates Positive Results In Amyotrophic Lateral Sclerosis Study 41

Sep 29, 2011: European Commission Grants Orphan Drug Status For Phytopharm's Cogane For Treatment Of Amyotrophic Lateral Sclerosis 42

Jul 28, 2011: Phytopharm's Cogane Receives FDA Orphan Drug Status 43

Nov 17, 2010: Phytopharm Initiates Phase II Study Of Cogane In Patients With Parkinson's Disease 43

Jun 14, 2010: Phytopharm Receives FDA Approval To Begin Phase II Clinical Trial Of Cogane 44

Apr 20, 2009: Phytopharm Announces The Commencement Of Clinical Study of Cogane In Patients With Parkinson's Disease 44

Jan 21, 2008: Phytopharm Announces $1.16 million Funding For Cogane 45

Appendix 46

Methodology 46

Coverage 46

Secondary Research 46

Primary Research 46

Expert Panel Validation 46

Contact Us 46

Disclaimer 47

To know more information on Purchase by Section, please send a mail to sales@kenresearch.com

List of Figures

Number of Products under Development by Stage of Development, H2 2017 7

Number of Products under Development by Therapy Areas, H2 2017 8

Number of Products under Development by Top 10 Indications, H2 2017 9

Number of Products by Mechanism of Actions, H2 2017 14

Number of Products by Stage and Mechanism of Actions, H2 2017 14

Number of Products by Routes of Administration, H2 2017 16

Number of Products by Stage and Routes of Administration, H2 2017 16

Number of Products by Molecule Types, H2 2017 18

Number of Products by Stage and Molecule Types, H2 2017 18

List of Tables

Number of Products under Development by Stage of Development, H2 2017 7

Number of Products under Development by Therapy Areas, H2 2017 8

Number of Products under Development by Indication, H2 2017 9

Number of Products under Development by Companies, H2 2017 10

Products under Development by Companies, H2 2017 11

Number of Products under Investigation by Universities/Institutes, H2 2017 12

Products under Investigation by Universities/Institutes, H2 2017 13

Number of Products by Stage and Mechanism of Actions, H2 2017 15

Number of Products by Stage and Route of Administration, H2 2017 17

Number of Products by Stage and Molecule Type, H2 2017 19

Pipeline by GlaxoSmithKline Plc, H2 2017 20

Pipeline by Treeway BV, H2 2017 20

Pipeline by UniQure NV, H2 2017 21

Dormant Projects, H2 2017 34

Single User License:
Report can be used by individual purchaser only

Site License:
Report can be shared by unlimited users within one corporate location, e.g. a regional office

Corporate User License:
Report can be shared globally by unlimited users within the purchasing corporation e.g. all employees of a single company

GlaxoSmithKline Plc

Treeway BV

UniQure NV

Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) Therapeutic Products under Development, Key Players in Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) Therapeutics, Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) Pipeline Overview, Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) Pipeline, Glial Cell Line Derived Neurotrophic Factor (Astrocyte Derived Trophic Factor or GDNF) Pipeline Assessment


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