Organ-On-Chip Global Market Opportunities And Strategies To 2021 Including: Lung-On-Chip, Heart-On-Chip, Liver-On-Chip, Intestine-On-Chip, Kidney-On-Chip, Skin-On-Chip, Blood-Brain-Barrier-On-Chip And Human-On-Chip Covering: CN Bio Innovations, Emulate, TissUse, Mimetas, Hurel, Nortis, InSphero, Tara Biosystems, AxoSim Technologies, Organovo, Ascendence And HemoShear
July 2018
105
About the Report
About the Report
Scientific advances in cell biology, microfabrication and microfluidics have led to the development of Organ-on-Chips (OOCs). OOCs are microfluidic 3D cell culture devices that closely mimic the key physiological functions of body organs. These chips are not designed to biomimic an entire organ, but simulate the physiology of a single functional unit of an organ system.
These microchips are one of the most exciting areas of scientific research as they have the distinguishing characteristic of emulating the human micro environment in vitro. This unique feature of OOCs is made possible by integrating biology with advanced engineering technologies.
OOC technology is still at an initial stage of research, development and commercialization. The players in the market are primarily university spinoffs involved in the commercialization of OOC prototypes developed in the universities. The key players include Emulate, CN-Bio Innovations, InSphero, Mimetas, TissUse, H�rel and Nortis. Currently OOCs are marketed primarily through sales agreements with end-users that involve collaboration of both parties in tailoring the OOCs to meet the end-user's requirements.
The global market for OOCs was valued at USD 20 million in 2016. It is expected to grow at a compound annual growth rate (CAGR) of 70% to reach USD 284 million by 2021. The small size of the market is mainly due to the fact that OOCs have not yet been fully commercialized. They are still in the research and development phase and are primarily being used by a limited number of end-users. The OOC market is expected to rise at this high CAGR due to an increase in the number of collaborative sales agreements between the pharmaceutical companies and university spin-offs and the entry of new advanced models of OOCs into the market. The anticipated launch of advanced organ-specific models and human-on-chip models is expected to further increase the growth rate of this market in future.
Further improvements in the design and manufacture of OOCs will probably replace animal models as subjects in preclinical drug evaluations in future. Overall, they have the potential to break an impasse in in-vitro drug discovery and development.
Products
Products
Lung-on-chip, Heart-on-chip, Liver-on-chip, Intestine-on-chip, Kidney-on-chip and Human-on-chip
Companies
North America: Emulate Inc., H�REL Corporation (H�REL), Nortis, Tara Biosystems, AxoSim Techologies LLC, Organovo, ASCENDANCE BIOTECHNOLOGY - HEPREGEN,
Europe: CN Bio Innovations, TissUse GmbH, Mimetas, InSphero, HemoShear, Roche Holding AG, Elvesys, Cherry Biotech, 4Dcell
Asia: Kyoto University
Table of Contents
Table of Contents
1 Executive Summary
2 Preface
3 Global Organ-On-Chip Market-Introduction
4 Organ-On-Chip Market Characteristics
4.1.1 Organs-On-Chips Origin And Significance
4.1.2 Organ-On-Chip Features
4.2 Organ-On-Chip Market-Product Analysis
4.2.1 Technical Description
4.2.2 Typical Organ-On-Chip Structure
4.2.3 Product Design Materials
4.2.4 Product Design Methodologies
5 Overview Of Organ-Specific Models
5.1 Lung-On-Chip
5.2 Heart-On-Chip
5.3 Liver-On-Chip
5.4 Intestine-On-Chip
5.5 Kidney-On-Chip
5.6 Skin-On-Chip
5.7 Blood-Brain-Barrier-On-Chip
5.8 Human-On-Chip
6 Organ-On-Chip Applications
7 Organ-On-Chip Commercialization
8 Organ-On-Chip Market Penetration
9 Price Information
10 Organ-On-Chip Market Trends and Models
10.1 Global Organ-On-Chip Market-Business Model
10.2 Five Forces Analysis
10.3 Market Trends
10.3.1 Developments In The Testing Of Human Organs-On-Chips
10.3.2 Organ-On-Chip Technology In Space
10.3.3 Automated Monitoring Of Organs-On-Chips
10.3.4 3D Printing Of Organs-On Chips
10.3.5 Manufacturers Tying Up With End-Users To Design Tailor-made Products
10.3.6 Investment In Integration Of Individual Organs-on-Chips Into Humans-on-Chips
10.3.7 Strong Focus On Development of Custom Organs-On-Chips
10.3.8 Manufacturers Work On Disease Models To Expedite Drug Testing
11 Global Organ-On-Chip Market-Market Size Analysis
11.1 Market Sizing Methodology
11.2 Global Market For Organs-on-Chips
11.2.1 Global Market For Organs-On-Chips (Historic 2013-2017)
11.2.2 Global Market For Organs-On-Chips (Forecast 2017-2021)
11.3 Global Organ-On-Chip Market Segmentation By Organ Type
11.4 Global Organ-On-Chip Market Segmentation By End-Users
11.4.1 Pharmaceuticals
11.4.2 Research Organizations
11.4.3 Consumer Goods and Cosmetics
11.4.4 Food and Beverages
11.4.5 Others
11.5 Global Organ-On-Chip Market Segmentation By Geography
11.5.1 North America
11.5.2 Europe
11.5.3 Asia
11.5.4 Rest Of World (ROW)
12 Global Organ-On-Chip Market-Drivers And Restraints
12.1 Drivers
12.1.1 Improved Drug Screening With Organs-On-Chips Will Drive Demand
12.1.2 Drug Testing Cost Savings to Drive Demand For OOCs
12.1.3 Government Funding Drives The Market For Organs-On-Chips
12.1.4 Ethical Concerns With Respect To Animal Models Will Drive The Organ-On-Chip Market
12.2 Restraints
12.2.1 Complex Manufacturing Techniques Are A Restraint On Organ-On-Chip Market Growth
12.2.2 Requirement For Specialized Equipment Will Be A Challenge For The Organ-On-Chip Market
12.2.3 Regulatory Hurdles For Drug Approvals
13 Global Organ-On-Chip Market-Funding Landscape
13.1.1 Funding Landscape-North America
13.1.2 Funding Landscape-Europe
13.1.3 Funding Landscape-Asia
13.1.4 Funding Landscape-ROW
14 Global Organ-On-Chip Market-Competitive Landscape
14.1 Key Players In The OOC Market
14.2 CN Bio Innovations
14.3 Emulate
14.4 TissUse
14.5 Mimetas
14.6 H�rel
14.7 Nortis
14.8 Insphero
14.9 Tara Biosystems
14.10 AxoSim Technologies LLC
14.11 Organovo
14.12 Ascendance
14.13 HemoShear
15 Global Organ-On-Chip Market-Conclusions and Strategies
15.1 Conclusions
15.2 Strategies
16 Appendix
16.1 Interview Summaries
16.1.1 Interview Number 1
16.1.2 Interview Number 2
16.1.3 Interview Number 3
16.1.4 Interview Number 4
16.1.5 Interview Number 5
16.1.6 Interview Number 6
16.1.7 Interview Number 7
16.2 Abbreviations
16.3 Research Methodology
16.4 Currencies
16.5 Research Inquiries
16.6 The Business Research Company
List of Figure
Figure 1: Global Organ-On-Chip Market, Typical Organ-On-Chip Structure
Figure 2: Global Organ-On-Chip Market, Lung-On-Chip Model
Figure 3: Global Organ-On-Chip Market, Heart-On-Chip Model
Figure 4: Global Organ-On-Chip Market, Liver-On-Chip Model
Figure 5: Global Organ-On-Chip Market, Intestine-On-Chip Model
Figure 6: Global Organ-On-Chip Market, Kidney-On-Chip Model
Figure 7: Global Organ-On-Chip Market, Skin-On-Chip Model
Figure 8: Global Organ-On-Chip Market, Blood-Brain-Barrier-On-Chip Model
Figure 9: Global Organ-On-Chip Market, Human-On-Chip Model
Figure 10: Global Organ-On-Chip Market, Typical Business Model Of OOC Companies
Figure 11: Global Organ-On-Chip Market, Five Forces Analysis
Figure 12: Global Organ-On-Chip Historic Market Size, 2013-2017, Value (USD million)
Figure 13: Global Organ-On-Chip Forecast Market Size, 2017-2021, Value (USD million)
Figure 14: Global Organ-On-Chip Market, Segmentation By Organ Type, 2017, (% share)
Figure 15: Global Organ-On-Chip Market Segmentation By End-Users, 2017, Value (USD million)
Figure 16: North America Organ-On-Chip Market, Historic Market Size, 2013-2017, Value (USD million)
Figure 17: North America Organ-On-Chip Market, Forecast Market Size, 2017-2021, Value (USD million)
Figure 18: Europe Organ-On-Chip Market, Historic Market Size, 2013-2017, Value (USD million)
Figure 19: Europe Organ-On-Chip Market, Forecast Market Size, 2017-2021, Value (USD million)
Figure 20: Asia Organ-On-Chip Market, Historic Market Size, 2013-2017, Value (USD million)
Figure 21: Asia Organ-On-Chip Market, Forecast Market Size, 2017-2021, Value (USD million)
Figure 22: ROW Organ-On-Chip Market, Historic Market Size, 2013-2017, Value (USD million)
Figure 23: ROW Organ-On-Chip Market, Forecast Market Size, 2017-2021, Value (USD million)
Figure 24: Global Organ-On-Chip Market, Predictability Scale Of Techniques In Drug Screening And Evaluation
Figure 25: Global Organ-On-Chip Market, Number Of New Drug Approvals By FDA And EMA, 2013-2016
Figure 26: Global Organ-On-Chip Market Funding Landscape Split By Regions, 2015-2017, Value, (USD million)
Figure 27: Global Organ-On-Chip Market Key Competitors Revenues, 2017 (USD million)
List of Table
Table 1: Global Organ-On-Chip Market, List Of Universities And Their Spin-offs
Table 2: Global Organ-On-Chip Market, Historic Market Size, 2013-2017, Value (USD million)
Table 3: Global Organ-On-Chip Market, Forecast Market Size, 2017-2021, Value (USD million)
Table 4: Global Organ-On-Chip Market,Segmentation By Organ Type, 2017, (% share)
Table 5: Global Organ-On-Chip Market, Segmentation By End-Users, 2017, Value (USD million)
Table 6: North America Organ-On-Chip Market, Historic Market Size, 2013-2017, Value (USD million)
Table 7: North America Organ-On-Chip Market, Forecast Market Size, 2017-2021, Value (USD million)
Table 8: Europe Organ-On-Chip Market, Historic Market Size, 2013-2017, Value (USD million)
Table 9: Europe Organ-On-Chip Market, Forecast Market Size, 2017-2021, Value (USD million)
Table 10: Asia Organ-On-Chip Market, Historic Market Size, 2013-2017, Value (USD million)
Table 11: Asia Organ-On-Chip Market, Forecast Market Size, 2017-2021, Value (USD million)
Table 12: ROW Organ-On-Chip Market, Historic Market Size, 2013-2017, Value (USD million)
Table 13: ROW Organ-On-Chip Market, Forecast Market Size, 2017-2021, Value (USD million)
Table 14: Global Organ-On-Chip Market, Top Pharmaceutical Companies-R&D Expenditures, 2015 and 2016, (USD billion)
Table 15: Global Organ-On-Chip Market, Number Of New Drug Approvals By FDA And EMA, 2013-2016
Table 16: Global Organ-On-Chip Market, Institutions Funded By NIH, 2017
Table 17: Global Organ-On-Chip Market, Institutions Funded By NCATS For Tissue Chip Testing Centers, 2016
Table 18: Global Organ-On-Chip Market, Institutions Funded By NCATS, 2017
Table 19: Global Organ-On-Chip Market, CN Bio Collaborations With Pharmaceutical Companies
Table 20: Global Organ-On-Chip Market, CN Bio Collaborations With Academic Institutions
Table 21: Global Organ-On-Chip Market, H�REL Products and its Description
Table 22: Global Organ-On-Chip Market, InSphero Products and its Description
Table 23: Global Organ-On-Chip Market, InSphero Collaborations With Academic Universities And Industries
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