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Report Title

Global In Vitro Toxicology Testing Market (Drivers, Restraints, Opportunities, Trends and Forecast) 2018-2024

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Global In Vitro Toxicology Testing Market (Drivers, Restraints, Opportunities, Trends and Forecast) 2018-2024


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Global In Vitro Toxicology Testing Market (Drivers, Restraints, Opportunities, Trends and Forecast) 2018-2024



Executive Summary

Global In Vitro Toxicology Testing Market-Drivers, Restraints, Opportunities, Trends, and Forecast: 2018-2024

Overview: In vitro toxicology involves the study of cells or tissues grown or maintained in precise lab conditions to observe the toxic properties of the compound. These testing methods help in inspecting the toxicity of xenobiotics at the cellular level in the laboratory without the interaction of complex physiological systemic effects that are often observed in living organisms. In vitro methods are commonly used in recent years as these can be correlated with in vivo studies and assist in understanding a particular in vivo response in any animal species. It is commonly employed by the pharmaceutical, chemical, food, cosmetic, medical device, and diagnostics industries to test the safety (toxicity) and efficacy of drugs, chemicals, biochemicals, materials, and preparations. Most of the information about the potential toxicity of drug substances are obtained from using animal models, but these tend to have significant limitations when translating them to human risk assessment. Although some basic toxicity testing using human cells in vitro is already a conventional method, many toxicologists are developing more sophisticated in vitro analyses using human-based cell models that can be more predictive about human health outcomes.

The market for in vitro toxicology testing is driven by high opposition to animal testing, increased cost related to animal-based toxicity testing, and increasing R&D expenditure for early stage toxicity testing. Whereas, the lack of in vitro models and decreased adoption rate are limiting the growth of the market to an extent.

Market Analysis: The global in vitro toxicology testing market is estimated to witness a CAGR of 8.2% during the forecast period 2018-2024. The global market is analyzed based on three segments-toxicology endpoints, industry type, and regions.

Regional Analysis: The regions covered in the report are North America, Europe, Asia Pacific, and Rest of the World (ROW). Europe is the major shareholder in the global in vitro toxicology testing market, followed by North America. The upsurge in the investments by the European Commission in R&D to develop substitute methods to in vivo testing is driving the demand in this region. Asia Pacific is expected to grow at a high CAGR during the forecast period due to increasing number of contract research organizations offering testing services, advancements in healthcare infrastructure, increasing investments in the biopharmaceutical sector, and upward economic conditions in this region.

Toxicology Endpoints Analysis: The in vitro toxicology testing market, by toxicology endpoints, is segmented into systemic toxicity, cytotoxicity testing, genotoxicity testing, ocular toxicity, organ toxicity, dermal toxicity, neurotoxicity, and others. Among these, systemic toxicity accounted for the highest market share in 2017 due to the availability of a wide range of sub-studies, which ensure total analysis of toxicity and safety margin of the testing compounds.

Industry Type Analysis: The in vitro toxicology testing market, by industry type, is segmented into pharmaceutical and biopharmaceutical, cosmetics, chemical, diagnostics, and food industry. The pharmaceutical and biopharmaceutical industry occupied significant market share in 2017 and the cosmetics industry is expected to hold a higher percentage during the forecast period. Increased support of regulatory authorities to use in vitro and in silico methods instead of animal testing to check toxicology is driving the growth of the cosmetic industry.

Key Players:

Laboratory Corporation of America Holdings, Charles River Laboratories, Inc., Bio-Rad Laboratories, GE Healthcare, Thermo Fisher Scientific, Eurofins Scientific, SGS SA, BioIVT, Agilent Technologies, Inc., Abbott Laboratories, Gentronix Limited, Promega Corporation, MB Research Laboratories, Evotec AG (Cyprotex plc), Catalent, Inc., Qiagen N.V., and niche players.

Competitive Analysis: There is an increase in collaborations between companies on in vitro testing of compounds. For instance, in December 2016, Evotec and Celgene entered into a drug discovery collaboration for neurodegenerative diseases. According to agreement terms, Celgene will use Evotec's unique induced pluripotent stem cell (iPSC) platform that enables systematic drug screening in patient-derived disease models. In June 2017, Censo Biotechnologies Ltd. collaborated with Evotec AG to source and provide patient-derived induced pluripotent stem cells to support Evotec's drug discovery iPSC platform. In addition, the companies are also coming up with new products for in vitro testing. For instance, in January 2018, STEMCELL Technologies Inc. released two product lines for organoid research that will enable scientists to create powerful models for studying human disease in the lab.

Benefits: The report provides complete details about the services offered by in vitro toxicology testing companies in various therapeutic verticals and regions. With that, key stakeholders can know about the major trends, drivers, investments, and vertical player's initiatives. Moreover, the report provides details about the major challenges that are going to impact on the market growth. Additionally, the report gives the complete details about the key business opportunities to key stakeholders to expand their business and capture the revenue in the specific verticals to analyze before investing or expanding the business in this market.

Key Stakeholders:

Table of Contents

1 INDUSTRY OUTLOOK 9

1.1 Industry overview 9

1.2 Importance of toxicology studies 10

2 Report Outline 11

2.1 Report Scope 11

2.2 Report Summary 11

2.3 Research Methodology 12

2.4 Report Assumptions 12

3 Market Snapshot 14

3.1 Market Definition-Infoholic Research 14

3.2 Advantages of In vitro testing 14

3.3 Segmented Addressable Market (SAM) 14

3.4 Trends of the in vitro toxicology testing market 15

3.5 Related Markets 16

3.5.1 In vivo toxicology 16

3.5.2 ADME Toxicology testing 16

3.5.3 Biologics safety testing 16

4 Market Outlook 18

4.1 Market segmentation 18

4.2 PEST Analysis 18

4.3 Porter 5(Five) Forces 19

5 Market Characteristics 21

5.1 DRO-Global In Vitro Toxicology Testing Market Dynamics 21

5.1.1 Drivers 21

5.1.1.1 High opposition to animal testing 21

5.1.1.2 Low cost associated with in vitro toxicology testing 22

5.1.2 Opportunities 22

5.1.2.1 Advent of new in vitro models 22

5.1.2.2 Upsurge in toxicology database will facilitate the use of in vitro testing methods 23

5.1.3 Restraints 24

5.1.3.1 Barriers in adopting in vitro testing methods 24

5.1.3.2 Deficiency of in vitro models to conduct complex studies 24

5.2 DRO-Impact Analysis 25

5.3 Key Stakeholders 26

6 Toxicity endpoints: Market Size and Analysis 28

6.1 Overview 28

6.2 Systemic toxicity testing 29

6.3 Cytotoxicity testing 29

6.4 Genotoxicity testing 29

6.5 Organ toxicity 30

6.6 Ocular toxicity 30

6.7 Dermal toxicity 30

6.8 Neurotoxicity 31

6.9 Others 31

7 Industry type: Market Size and Analysis 32

7.1 Overview 32

7.2 Pharma and biopharma industry 33

7.3 Cosmetics industry 34

7.4 Chemical industry 35

7.5 Food industry 36

7.6 Diagnostics industry 37

8 Regions: Market Size and Analysis 39

8.1 Overview 39

8.2 North America 40

8.3 Europe 41

8.4 Asia Pacific 42

8.5 Rest of the World 44

9 Competitive Landscape 45

9.1 Overview 45

10 Vendor Profiles 47

10.1 Laboratory Corporation of America Holdings (LABCORP) 47

10.1.1 Overview 47

10.1.2 Laboratory Corporation of America Holdings: Recent Developments 48

10.1.3 Business Units 51

10.1.4 Geographic Revenue 52

10.1.5 Business Focus 52

10.1.6 SWOT Analysis 53

10.1.7 Business Strategies 53

10.2 Charles River Laboratories, Inc. 54

10.2.1 Overview 54

10.2.2 Charles River Laboratories, Inc.: Recent Developments 56

10.2.3 Business Units 59

10.2.4 Geographic Revenue 59

10.2.5 Business Focus 60

10.2.6 SWOT Analysis 61

10.2.7 Business Strategies 61

10.3 Thermo Fisher Scientific, Inc. 62

10.3.1 Overview 62

10.3.2 Business Units 67

10.3.3 Geographic Revenue 68

10.3.4 Business focus 69

10.3.5 SWOT analysis 70

10.3.6 Business Strategy 70

10.4 Eurofins Scientific 71

10.4.1 Overview 71

10.4.2 Geographic Revenue 74

10.4.3 Business focus 75

10.4.4 SWOT analysis 75

10.4.5 Business Strategy 76

10.5 Agilent Technologies Inc. 77

10.5.1 Overview 77

10.5.2 Business Units 81

10.5.3 Geographic Revenue 82

10.5.4 Business Focus 83

10.5.5 SWOT Analysis 84

10.5.6 Business Strategies 84

11 Companies to Watch For 86

11.1 SGS SA 86

11.1.1 Overview 86

11.2 Abbott Laboratories 88

11.2.1 Overview 88

11.3 GE Healthcare 90

11.3.1 Overview 90

11.4 BioReliance Corporation (a subsidiary of Merck KGaA) 93

11.4.1 Overview 93

11.5 BioIVT 94

11.5.1 Overview 94

11.6 Bio-Rad Laboratories 96

11.6.1 Overview 96

11.6.2 Bio-Rad Laboratories: Recent Developments 97

11.7 Catalent, Inc. 98

11.7.1 Overview 98

11.7.2 Catalent Inc: Recent Developments 98

11.8 Evotec AG (Cyprotex plc) 100

11.8.1 Overview 100

11.8.2 Evotec AG: Recent Developments 101

11.9 Gentronix Limited 104

11.9.1 Overview 104

11.9.2 Gentronix Limited: Recent Developments 104

11.10 Promega Corporation 105

11.10.1 Overview 105

11.10.2 Promega Corporation: Recent Developments 106

11.11 Qiagen N.V. 106

11.11.1 Overview 106

12 Annexure 111

12.1 Abbreviations 111

To know more information on Purchase by Section, please send a mail to sales@kenresearch.com

Charts

CHART 1 RESEARCH METHODOLOGY OF GLOBAL IN VITRO TOXICOLOGY TESTING MARKET 12

CHART 2 GLOBAL IN VITRO TOXICOLOGY TESTING MARKET REVENUE, 2017-2024 (USD MILLION) 15

CHART 3 SEGMENTATION OF GLOBAL IN VITRO TOXICOLOGY TESTING MARKET 18

CHART 4 PEST ANALYSIS OF GLOBAL IN VITO TOXICOLOGY TESTING MARKET 18

CHART 5 PORTER 5 FORCES ON GLOBAL IN VITRO TOXICOLOGY TESTING MARKET 19

CHART 6 DRO-IMPACT ANALYSIS OF GLOBAL IN VITRO TOXICOLOGY TESTING MARKET 25

CHART 7 KEY STAKEHOLDERS 26

CHART 8 GLOBAL IN VITRO TOXICOLOGY TESTING MARKET BY TOXICOLOGY ENDPOINTS SEGMENTATION, 2017 (%) 28

CHART 9 GLOBAL IN VITRO TOXICOLOGY TESTING MARKET BY INDUSTRY TYPE SEGMENTATION, 2017 (%) 32

CHART 10 GLOBAL IN VITRO TOXICOLOGY TESTING MARKET BY INDUSTRY TYPE SEGMENTATION, 2024 (%) 32

CHART 11 GLOBAL PHARMA AND BIOPHARMA INDUSTRY MARKET REVENUE FORECAST, 2017-2024 (USD MILLION) 34

CHART 12 GLOBAL COSMETICS INDUSTRY MARKET REVENUE FORECAST, 2017-2024 (USD MILLION) 35

CHART 13 GLOBAL CHEMICAL INDUSTRY MARKET REVENUE FORECAST, 2017-2024 (USD MILLION) 36

CHART 14 GLOBAL FOOD INDUSTRY MARKET REVENUE FORECAST, 2017-2024 (USD MILLION) 37

CHART 15 GLOBAL DIAGNOSTICS INDUSTRY MARKET REVENUE FORECAST, 2017-2024 (USD MILLION) 37

CHART 16 GLOBAL IN VITRO TOXICOLOGY TESTING MARKET BY GEOGRAPHICAL SEGMENTATION, 2017 (%) 39

CHART 17 IN VITRO TOXICOLOGY TESTING MARKET REVENUE IN NORTH AMERICA, 2017-2024 (USD MILLION) 40

CHART 18 IN VITRO TOXICOLOGY TESTING MARKET REVENUE IN EUROPE, 2017-2024 (USD MILLION) 42

CHART 19 IN VITRO TOXICOLOGY TESTING MARKET REVENUE IN ASIA PACIFIC, 2017-2024 (USD MILLION) 43

CHART 20 IN VITRO TOXICOLOGY TESTING MARKET REVENUE IN REST OF THE WORLD, 2017-2024 (USD MILLION) 44

CHART 21 LABORATORY CORPORATION OF AMERICA HOLDINGS: OVERVIEW SNAPSHOT 49

CHART 22 LABORATORY CORPORATION OF AMERICA HOLDINGS: BUSINESS UNITS REVENUE 51

CHART 23 LABORATORY CORPORATION OF AMERICA HOLDINGS: GEOGRAPHICAL REVENUE 52

CHART 24 LABORATORY CORPORATION OF AMERICAL HOLDINGS: SWOT ANALYSIS 53

CHART 25 CHARLES RIVER LABORATORIES, INC.: OVERVIEW SNAPSHOT 58

CHART 26 CHARLES RIVER LABORATORIES, INC.: BUSINESS UNITS 59

CHART 27 CHARLES RIVER LABORATORIES: GEOGRAPHIC REVENUE 59

CHART 28 CHARLES RIVER LABORATORIES, INC.: SWOT ANALYSIS 61

CHART 29 THERMO FISHER SCIENTIFIC: OVERVIEW SNAPSHOT 66

CHART 30 THERMO FISHER SCIENTIFIC, INC.: BUSINESS UNITS 67

CHART 31 THERMO FISHER SCIENTIFIC, INC.: GEOGRAPHIC REVENUE 68

CHART 32 THERMO FISHER SCIENTIFIC, INC.: SWOT ANALYSIS 70

CHART 33 EUROFINS SCIENTIFIC: OVERVIEW SNAPSHOT 73

CHART 34 EUROFINS SCIENTIFIC: GEOGRAPHIC REVENUE 74

CHART 35 EUROFINS SCIENTIFIC: SWOT ANALYSIS 75

CHART 36 AGILENT TECHNOLOGIES INC.: OVERVIEW SNAPSHOT 80

CHART 37 AGILENT TECHNOLOGIES, INC.: BUSINESS UNITS 81

CHART 38 AGILENT TECHNOLOGIES INC.: GEOGRAPHIC REVENUE 82

CHART 39 AGILENT TECHNOLOGIES, INC.: SWOT ANALYSIS 84

Tables

TABLE 1 GLOBAL IN VITRO TOXICOLOGY TESTING MARKET REVENUE BY REGIONS, 2017-2024 (USD MILLION) 39

TABLE 2 OTHER PROMINENT VENDORS OF IN VITRO TOXICOLOGY TESTING MARKET 46

TABLE 3 LABORATORY CORPORATION OF AMERICA HOLDINGS: PRODUCT OFFERINGS 48

TABLE 4 CHARLES RIVER LABORATORIES, INC.: OFFERINGS 55

TABLE 5 THERMO FISHER SCIENTIFIC, INC.: PRODUCT OFFERINGS 63

TABLE 6 THERMO FISHER SCIENTIFIC, INC: RECENT DEVELOPMENTS 64

TABLE 7 EUROFINS SCIENTIFIC: PRODUCT OFFERINGS 71

TABLE 8 EUROFINS SCIENTIFIC: RECENT DEVELOPMENTS 71

TABLE 9 AGILENT TECHNOLOGIES INC: PRODUCT OFFERINGS 78

TABLE 10 AGILENT TECHNOLOGIES INC: RECENT DEVELOPMENTS 78

TABLE 11 SGS SA: SNAPSHOT 86

TABLE 12 SGS SA: RECENT DEVELOPMENTS 87

TABLE 1 ABBOTT LABORATORIES: SNAPSHOT 88

TABLE 2 ABBOTT LABORATORIES: RECENT DEVELOPMENTS 88

TABLE 3 GE HEALTHCARE: SNAPSHOT 91

TABLE 4 GE HEALTHCARE: RECENT DEVELOPMENTS 91

TABLE 5 BIORELIANCE CORPORATION: SNAPSHOT 93

TABLE 6 BIORELIANCE CORPORATION: RECENT DEVELOPMENTS 94

TABLE 7 BIOIVT: SNAPSHOT 95

TABLE 8 BIOIVT: RECENT DEVELOPMENTS 95

TABLE 9 BIO-RAD LABORATORIES: SNAPSHOT 96

TABLE 10 CATALENT, INC.: SNAPSHOT 98

TABLE 11 EVOTEC AG: SNAPSHOT 100

TABLE 12 GENTRONIX LIMITED: SNAPSHOT 104

TABLE 13 PROMEGA CORPORATION: SNAPSHOT 105

TABLE 14 QIAGEN N.V.: SNAPSHOT 107

TABLE 15 QIAGEN N.V.: RECENT DEVELOPMENTS 107

America Holdings, Charles River Laboratories, Inc., Bio-Rad Laboratories, GE Healthcare, Thermo Fisher Scientific, Eurofins Scientific, SGS SA, BioIVT, Agilent Technologies, Inc., Abbott Laboratories, Gentronix Limited, Promega Corporation, MB Research Laboratories, Evotec AG (Cyprotex plc), Catalent, Inc., Qiagen N.V., and niche players.


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